University of Nottingham · School of Pharmacy
United Kingdom, Nottingham
2 Job openings at this institution
Job description
Phd
Studentships available at the University of Nottingham to start Oct
2016. Highly motivated individuals are sought for PhD positions in
protein crystallography and structure based drug design.
Description of project1: This is a 4 year studentship. Staphylococci are extremely common human commensals, which have been implicated in systemic infections in hospitals, biofilm formation in surgical devices and implants, industrial fouling and food spoilage. The auxiliary gene regulation in staphylococci controls important bacterial functions, such as virulence and adhesion to surfaces (biofilm formation). AgrB is a key protein responsible for preprocessing of the signaling molecule, AIP, which mediates bacterial communications and quorum sensing. Pharmacological regulation of this protein can control bacterial behavior, attenuate virulence and inhibit biofilm formation. AgrB is a 22 kDa membrane protein with predicted six helical TMD topology and the 3D structure is unknown. The project involves crystallisation and X-ray diffraction analysis at the synchrotron (diamond or ESRF) to enable crystal structure determination. In addition ArgB complexes with substrate mimetic peptide or inhibitor will also be determined. The resulting complex structures are likely to prove most informative for identifying the key molecular features of the AgrB active site conformation and substrate/inhibitor recognition and ultimately facilitate the development of novel antimicrobials to combat antimicrobial resistance (J Med Chem. 2014 Mar 27;57(6):2813-9., Structure. 2013 Sep 3;21(9):1659-71, PLoS Pathog. 2013;9(7):e1003508.) This is a University of Nottingham School of Pharmacy funded studentship (EU applicants only) as a collaboration between the groups of Jonas Emsley, Weng Chan and Paul Williams and is supported by a multidisciplinary team of postdoctoral researchers with complementary expertise in chemistry and microbiology.
For enquiries please contact Jonas Emsley via the APPLY button and send a cv.
Dr Jonas Emsley
Professor of Macromolecular Crystallography,
Division of Medicinal Chemistry & Structural Biology,
Centre for Biomolecular Sciences,
School of Pharmacy,
University of Nottingham,
University Park,
Nottingham.
NG72RD
Tel:
+44 1158467092
Fax: +44 1158468002
http://www.nottingham.ac.uk/research/groups/structural-biology/index.aspx
Description of project1: This is a 4 year studentship. Staphylococci are extremely common human commensals, which have been implicated in systemic infections in hospitals, biofilm formation in surgical devices and implants, industrial fouling and food spoilage. The auxiliary gene regulation in staphylococci controls important bacterial functions, such as virulence and adhesion to surfaces (biofilm formation). AgrB is a key protein responsible for preprocessing of the signaling molecule, AIP, which mediates bacterial communications and quorum sensing. Pharmacological regulation of this protein can control bacterial behavior, attenuate virulence and inhibit biofilm formation. AgrB is a 22 kDa membrane protein with predicted six helical TMD topology and the 3D structure is unknown. The project involves crystallisation and X-ray diffraction analysis at the synchrotron (diamond or ESRF) to enable crystal structure determination. In addition ArgB complexes with substrate mimetic peptide or inhibitor will also be determined. The resulting complex structures are likely to prove most informative for identifying the key molecular features of the AgrB active site conformation and substrate/inhibitor recognition and ultimately facilitate the development of novel antimicrobials to combat antimicrobial resistance (J Med Chem. 2014 Mar 27;57(6):2813-9., Structure. 2013 Sep 3;21(9):1659-71, PLoS Pathog. 2013;9(7):e1003508.) This is a University of Nottingham School of Pharmacy funded studentship (EU applicants only) as a collaboration between the groups of Jonas Emsley, Weng Chan and Paul Williams and is supported by a multidisciplinary team of postdoctoral researchers with complementary expertise in chemistry and microbiology.
For enquiries please contact Jonas Emsley via the APPLY button and send a cv.
Dr Jonas Emsley
Professor of Macromolecular Crystallography,
Division of Medicinal Chemistry & Structural Biology,
Centre for Biomolecular Sciences,
School of Pharmacy,
University of Nottingham,
University Park,
Nottingham.
NG72RD
Tel:
+44 1158467092Fax: +44 1158468002
http://www.nottingham.ac.uk/research/groups/structural-biology/index.aspx
Desired skills and experience
Undergraduates
holding or expecting to gain a Bachelor’s degree (or equivalent
international qualification) with First Class or 2.1 honours in a
relevant discipline including biophysics, biochemistry, biological
sciences, chemistry, microbiology. A 2:1 (upper second class) honours
degree (or international equivalent) may be acceptable depending on the
candidate's academic background, including e.g. strong performance
(predicted or achieved) in a Master's degree.
About the employer
The
School welcomes applications from all candidates and you can read more
about our commitment to equality and diversity at
http://tiny.cc/UoNPharmEandD
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