In this week's issue in Science Signaling

Research Articles
GPCR Signaling Purinergic P2Y6 receptors heterodimerize with angiotensin AT1 receptors to promote angiotensin II-induced hypertension Akiyuki Nishimura et al. Aging changes the response of blood vessels to angiotensin II, contributing to hypertension. Cell Biology ESCRT proteins restrict constitutive NF-κB signaling by trafficking cytokine receptors Agnieszka Mamińska et al. Proteins required for trafficking internalized cytokine receptors prevent the spurious activation of NF-κB signaling.
Editors' Choice
Metabolism SerpinB1 improves insulin sensitivity Annalisa M. VanHook A protease inhibitor secreted by the liver enables pancreatic β cells to compensate for reduced insulin sensitivity. Cancer Hypoxia micromanages glioma Leslie K. Ferrarelli Hypoxia alters microRNA biogenesis in glioma cells to promote adaptation in the tumor microenvironment. Cancer Protein homeostasis limiting cancer Wei Wong A protein involved in protein homeostasis limits the maturation of IGF1R and the overproduction of blood cells. Medicine Papers of note in Science Translational Medicine Nancy R. Gough This week's articles feature insights into diacylglycerol kinase in the immune disorder XLP-1, allergy in infants, and the neurological disease fragile X syndrome. Cell Biology Papers of note in Science Nancy R. Gough This week's articles feature insights into how a micropeptide enhances muscle performance and how an energy-sensing kinase triggers mitochondrial fragmentation.