MSc position - Functional Genomics

National Institute of Health Dr. Ricardo Jorge · Department of Human Genetics

Portugal, Lisbon

 

 

Job description

The Genomic Diseases group is seeking highly motivated candidates with a Master degree for a research fellowship in Functional Genomics and related fields. The candidate will be integrated within a Collaborative Research Project between Harvard Medical School and Portugal, titled “Next-Gen Cytogenetics Enters Clinical Care and Annotates the Human Genome” (HMS - HMSP ICT/0016/2013), financed by FCT.

This project aims to contribute to the introduction of Next Generation Sequencing (NGS) for the identification of genomic or chromosomal rearrangements at a nucleotide resolution. It also aims to understand the molecular pathogenesis of the chromosome rearrangements-associated developmental disorders and diseases, contributing to an improved prediction of their phenotypic consequences.
The main activities developed by the research fellow include, among others:

• Establishment and maintenance of cell cultures including iPSCs;
• Expression studies (RNASeq, arrays and TaqMan expression assay);
• Protein studies mainly Western blot analysis;
• Transgenic model and bioinformatics.

The fellowship is available for 12 months, renewable until the conclusion of the project, with an estimate starting in December 2015. It has a stipend of 980€/month, in agreement with the regulations of FCT, I.P. (http://alfa.fct.mctes.pt/apoios/bolsas/valores). For additional information consult the legislation, law Nº. 40/2004, of 18th of August (Estatuto do Bolseiro de Investigação Científica), revised in Decree-Law nº 202/2012, from 27th of August (Regulamento de Bolsas de Investigação da Fundação para a Ciência e a Tecnologia, I.P. — 2012).
The work will be mostly carried out at the Departamento de Genética Humana, Instituto Nacional de Saúde Dr. Ricardo Jorge, IP (Av. Padre Cruz, 1649-016 Lisbon, Portugal), under the supervision of Dezso David PhD.

• Curriculum Vitae
• Motivation letter detailing your interest and previous experience
• Two referees with their contact details.

For additional information please contact Dezso David PhD (telephone: +351 217519322; email: dgap.pt@insa.min-saude.pt)

Desired skills and experience

Candidates should have a Master Degree in Functional Genomics or in a related field in Biological Sciences. Experience in a relevant area of the project is highly desirable, such as NGS or expression arrays, genomic interactions or long-range gene regulation (Hi-C) studies, establishment of pluripotent cells and other areas of molecular biology. Applications will be evaluated on the basis of CV/publication record (40%) and previous experience (60%).