Job description
Improving Saccharomyces Cerevisiae as Synthetic Biology Chassis
Replacement of petrochemistry by bio-based processes is key to sustainable development and requires microbes equipped with novel-to-nature capabilities. The efficiency of such engineered microbes strongly depends on their native metabolic networks. However, aeons of evolution have optimized these networks for fitness in nature rather than for industrial performance. As a result, central metabolic networks are complex and encoded by mosaic microbial genomes in which genes, irrespective of their function, are scattered over the genome and chromosomes. This absence of a modular organization tremendously restricts genetic accessibility and presents a major hurdle for fundamental understanding and rational engineering of central metabolism. The goal of the project is to construct synthetic microbial platforms which will enable experimenters to remodel the core machinery of microbes at will. This challenging and innovative project paves the way for a modular approach to engineering of central metabolism.
This position is funded by an ERC consolidator grant awarded to Dr. Pascale Daran-Lapujade for an ambitious project that will be carried by a post-doctoral fellow, four PhD students and a technician. The work of these six persons will be tightly connected and requires a strong drive for team work.
To apply send your application including cover letter to: Delft_University_o-id5rkmi-857928@jobs.researchgate.net or click for more details
Replacement of petrochemistry by bio-based processes is key to sustainable development and requires microbes equipped with novel-to-nature capabilities. The efficiency of such engineered microbes strongly depends on their native metabolic networks. However, aeons of evolution have optimized these networks for fitness in nature rather than for industrial performance. As a result, central metabolic networks are complex and encoded by mosaic microbial genomes in which genes, irrespective of their function, are scattered over the genome and chromosomes. This absence of a modular organization tremendously restricts genetic accessibility and presents a major hurdle for fundamental understanding and rational engineering of central metabolism. The goal of the project is to construct synthetic microbial platforms which will enable experimenters to remodel the core machinery of microbes at will. This challenging and innovative project paves the way for a modular approach to engineering of central metabolism.
This position is funded by an ERC consolidator grant awarded to Dr. Pascale Daran-Lapujade for an ambitious project that will be carried by a post-doctoral fellow, four PhD students and a technician. The work of these six persons will be tightly connected and requires a strong drive for team work.
To apply send your application including cover letter to: Delft_University_o-id5rkmi-857928@jobs.researchgate.net or click for more details
Desired skills and experience
Applicants
should have an MSc with a strong background in molecular biology and
genetics. It is also recommended that the candidate shows keen interest
in physiology, biochemistry and more generally genomics. Experience with
top-of-the-art synthetic biology techniques is appreciated. Candidates
are expected to have excellent communication skills and team spirit.
Fluency in English, both written and spoken, is a requirement for this
position.
About the employer
The
Department of Biotechnology of the Delft University of Technology is
internationally leading in industrial biotechnology research. Its
Industrial Microbiology section, led by Prof. Jack Pronk, focuses on
quantitative analysis and engineering of metabolic fluxes and metabolic
regulation in industrial micro-organisms. A broad range of techniques is
applied for this research, including chemostat cultivation, genetic
modification, analysis of intra- and extracellular metabolites, DNA
microarrays, whole genome sequencing and flow cytometry.
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