In this week's issue: Science Signaling

Science Signaling Table of Contents

Editorial Guides

Signal Transduction 2015: Signaling Breakthroughs of the Year Elizabeth M. Adler Signaling research advances aid in understanding cellular and organismal regulation, as well as having biomedical, agricultural, and industrial implications.

Research Articles

Host-Pathogen Interactions Rosmarinic acid is a homoserine lactone mimic produced by plants that activates a bacterial quorum-sensing regulator Andrés Corral-Lugo et al. Plants release rosmarinic acid, which mimics bacterial quorum-sensing signals, to interfere with bacterial communication. Vascular Biology Inclusion bodies enriched for p62 and polyubiquitinated proteins in macrophages protect against atherosclerosis Ismail Sergin et al. Sequestration of aggregated proteins by p62 prevents macrophages from exacerbating atherosclerosis. Systems Immunology Comprehensive RNAi-based screening of human and mouse TLR pathways identifies species-specific preferences in signaling protein use Jing Sun et al. Comparative analysis of mouse and human macrophages reveals conserved and species-specific use of Toll-like receptor signaling components.

Podcasts

Signal Transduction Science Signaling Podcast for 5 January 2016: New directions in signaling research Michael B. Yaffe et al. Science Signaling editors discuss the current state of signal transduction research and the journal's place in this dynamic landscape.

Editors' Choice

Neuroscience Impairing cognition with TNF-α Nancy R. Gough Hippocampal astrocytes stimulated by TNF-α contribute to cognitive defects. Developmental Biology Allosteric regulation of Warts Annalisa M. VanHook Hippo pathway regulators allosterically switch the conformation of the kinase Warts. Metabolism Reprogramming lipid metabolism to boost antiviral responses Wei Wong Changes in cholesterol biosynthetic flux affect the sensitivity of an antiviral immune pathway. Medicine Papers of note in Science Translational Medicine Nancy R. Gough This week's articles feature insights into TRP channels in preterm labor and an antibody treatment for diabetes. Structural Biology Papers of note in Science Nancy R. Gough Three articles provide insights into a protein complex that enables cells to sense leucine and regulate metabolism.