This Week in Science

Cancer

The transcription factor ATF2 promotes melanoma metastasis by suppressing protein fucosylation

Eric Lau et al.

Suppressing ATF2 or supplementing the diet with fucose impairs growth and metastasis of melanoma in mice.

Cancer

Pleiotrophin promotes vascular abnormalization in gliomas and correlates with poor survival in patients with astrocytomas

Lei Zhang et al.

Secretion of pleiotrophin by aggressive gliomas triggers the formation of abnormal blood vessels by endothelial cells.

Host-Pathogen Interactions

The microRNA miR-485 targets host and influenza virus transcripts to regulate antiviral immunity and restrict viral replication

Harshad Ingle et al.

A single miRNA exhibits both an inhibitory effect on the antiviral response and an antiviral effect on viral replication.