PhD project: Decoding the functions of ubiquitin in the cellular response to DNA damage

Dynamic modification of proteins with ubiquitin after DNA damage has been shown to play a central role in all DNA repair pathways. In this regard, protein ubiquitination has most frequently been associated with the recruitment of DNA repair factors - many containing ubiquitin-binding domains -to DNA lesions and lesion flanking chromatin. The aim of this project is to identify the protein substrates and characterize the functions of selected nuclear ubiquitin ligases that are important for cellular survival after DNA damage. To this end, the prospective PhD student will employ a range of methods including mass spectrometry-based proteomics as well as advanced cell biological and biochemical methods such as flow cytometry, confocal microscopy, next generation sequencing and genome editing techniques.



We offer

• The possibility to work on a cutting-edge project using state-of-the-art technology in a highly motivated research team

• A stimulating, diverse and international research environment

• Advanced training opportunities

• A competitive stipend



Required qualifications

• Master or Diploma

• Motivation to solve complex biological problems

• Excellent communication skills



Starting date: 1 April 2016 or later

Duration of stipend: 3 years, with the possibility of extension

Deadline for registration (exclusively online via web form): 8 November 2015



For further questions and contact information please check our website:

http://www.imb.de/PhD



Please apply exclusively via our online form