People who grow up on dairy farms only rarely develop asthma or allergies. This is probably because as children, they breathe
air containing bacterial components, which reduce the overall reactivity of the immune system. Schuijs et al.
chronically exposed mice to bacterial endotoxin before they received an
allergic stimulus. The protocol indeed protected
them from developing an allergic response.
Protection relied on a particular enzyme: A20. In humans, a variant of
A20 correlates
with increased susceptibility to asthma and allergy
in children growing up on farms. To read more Click
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